Multiprobe FISH for Enhanced Detection of Bladder Cancer in Voided Urine Specimens and Bladder Washings
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چکیده
منابع مشابه
Multiprobe FISH for enhanced detection of bladder cancer in voided urine specimens and bladder washings.
The aim of this study was to evaluate the UroVysion (Vysis, Downers Grove, IL) fluorescence in situ hybridization (FISH) test for improved detection of bladder cancer in urinary specimens. Three groups of specimens were examined, including voided urine specimens (1) collected before resection of bladder cancer, (2) from cystoscopically negative bladders of patients with previous bladder cancer,...
متن کاملDiagnosis of bladder cancer from the voided urine specimens using multi-target fluorescence in situ hybridization
The present study aimed to evaluate the diagnostic value of chromosomal analysis by fluorescence in situ hybridization (FISH) for bladder cancer in light of the histological diagnosis. Several valuable observations using FISH technologies in voided urine cells were also reported. The multi-target FISH-containing probes for the centromeres of chromosomes 3, 7 and 17 and the 9p21 locus were appli...
متن کاملA 3-plex methylation assay combined with the FGFR3 mutation assay sensitively detects recurrent bladder cancer in voided urine Running title: Urine biomarkers for recurrent bladder cancer detection
Raju Kandimalla, Roy Masius, Willemien Beukers, Chris H. Bangma, Torben F. Orntoft, Lars Dyrskjot, Nikki van Leeuwen, Hester Lingsma, Angela A. G. van Tilborg, Ellen C. Zwarthoff Department of Pathology, Erasmus MC, Rotterdam, The Netherlands Department of Urology, Erasmus MC, Rotterdam, The Netherlands Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark Department of ...
متن کاملHypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients.
PURPOSE We aimed to investigate the methylation pattern in bladder cancer and assess the diagnostic potential of such epigenetic changes in urine. EXPERIMENTAL DESIGN The methylation status of 7 genes (RARbeta, DAPK, E-cadherin, p16, p15, GSTP1, and MGMT) in 98 cases of bladder transitional cell carcinoma and 4 cases of carcinoma in situ was analyzed by methylation-specific PCR. Twenty-two ca...
متن کاملUrine markers for detection and surveillance of bladder cancer.
OBJECTIVES Bladder cancer detection and surveillance includes cystoscopy and cytology. Urinary cytology is limited by its low sensitivity for low-grade tumors. Urine markers have been extensively studied to help improve the diagnosis of bladder cancer with the goal of complementing or even replacing cystoscopy. However, to date, no marker has reached widespread use owing to insufficient evidenc...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2001
ISSN: 0002-9173,1943-7722
DOI: 10.1309/k5p2-4y8b-7l5a-faa9